Placeholder inside define constant mysql statement

Placeholder inside define constant mysql statement

Hey everyone I created a define constant mysql statement, using a where
condition with one variable, is no problem but i encountered an error,
when the placeholder the variable is array like this one.
define ("GET_EMAIL_NOT_REG", "SELECT DISTINCT email
FROM accounts
WHERE sent = 0
AND active > 0
AND email NOT IN ( ? )");
Pls correct me with the proper syntax as I encountered error using that code.